Mutations in VP1 and 5′-UTR affect enterovirus 71 virulence

Enterovirus 71 (EV71) is a major cause of hand, foot and mouth disease (HFMD). The current EV71 propagating in Vero (EV-V) or sub-passaged in RD (EV-R) cells was used as a pathogen. Interestingly, EV-R exhibited differential virulence; challenging human scavenger receptor class B2-expressing (hSCARB...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Chang, Ching-Kun, Wu, Shang-Rung, Chen, Ying-Chin, Lee, Kuen-Jin, Chung, Nai-Hsiang, Lu, Yi-Ju, Yu, Shu-Ling, Liu, Chia-Chyi, Chow, Yen-Hung
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923339/
https://ncbi.nlm.nih.gov/pubmed/29703921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25091-7
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