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Whole exome sequencing reveals rare variants linked to congenital pouch colon

We demonstrate the application of whole exome sequencing to discover the rare variants for congenital pouch colon, acronymed CPC. For 18 affected individuals in a total of 64 samples, we sequenced coding regions to a mean coverage of 100×. A sufficient depth of ca. 94% of targeted exomes was achieve...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Mathur, Praveen, Medicherla, Krishna Mohan, Chaudhary, Spandan, Patel, Mruduka, Bagali, Prashanth, Suravajhala, Prashanth
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923232/
https://ncbi.nlm.nih.gov/pubmed/29703930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24967-y
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