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Human rhinovirus internal ribosome entry site element enhances transgene expression in transfected CHO-S cells

Chinese hamster ovary (CHO) cells are mainly used for recombinant protein production. However, the unstable transgene expression and lower transgene copy numbers are the major issues need to be resolved. Here, eleven internal ribosome entry site (IRES) elements from viral and cellular IRES were eval...

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書目詳細資料
發表在:Sci Rep
Main Authors: Chai, Yu-rong, Ge, Meng-meng, Wei, Ting-ting, Jia, Yan-long, Guo, Xiao, Wang, Tian-yun
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923211/
https://ncbi.nlm.nih.gov/pubmed/29703950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25049-9
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