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Human rhinovirus internal ribosome entry site element enhances transgene expression in transfected CHO-S cells

Chinese hamster ovary (CHO) cells are mainly used for recombinant protein production. However, the unstable transgene expression and lower transgene copy numbers are the major issues need to be resolved. Here, eleven internal ribosome entry site (IRES) elements from viral and cellular IRES were eval...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chai, Yu-rong, Ge, Meng-meng, Wei, Ting-ting, Jia, Yan-long, Guo, Xiao, Wang, Tian-yun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923211/
https://ncbi.nlm.nih.gov/pubmed/29703950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25049-9
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