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Human rhinovirus internal ribosome entry site element enhances transgene expression in transfected CHO-S cells

Chinese hamster ovary (CHO) cells are mainly used for recombinant protein production. However, the unstable transgene expression and lower transgene copy numbers are the major issues need to be resolved. Here, eleven internal ribosome entry site (IRES) elements from viral and cellular IRES were eval...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Chai, Yu-rong, Ge, Meng-meng, Wei, Ting-ting, Jia, Yan-long, Guo, Xiao, Wang, Tian-yun
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923211/
https://ncbi.nlm.nih.gov/pubmed/29703950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25049-9
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