Tapering Courses of Oral Vancomycin Induce Persistent Disruption of the Microbiota That Provide Colonization Resistance to Clostridium difficile and Vancomycin-Resistant Enterococci in Mice

Vancomycin taper regimens are commonly used for the treatment of recurrent Clostridium difficile infections. One rationale for tapering and pulsing of the dose at the end of therapy is to reduce the selective pressure of vancomycin on the indigenous intestinal microbiota. Here, we used a mouse model...

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Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Tomas, Myreen E., Mana, Thriveen S. C., Wilson, Brigid M., Nerandzic, Michelle M., Joussef-Piña, Samira, Quiñones-Mateu, Miguel E., Donskey, Curtis J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2018
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923165/
https://ncbi.nlm.nih.gov/pubmed/29530853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02237-17
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