Tapering Courses of Oral Vancomycin Induce Persistent Disruption of the Microbiota That Provide Colonization Resistance to Clostridium difficile and Vancomycin-Resistant Enterococci in Mice

Vancomycin taper regimens are commonly used for the treatment of recurrent Clostridium difficile infections. One rationale for tapering and pulsing of the dose at the end of therapy is to reduce the selective pressure of vancomycin on the indigenous intestinal microbiota. Here, we used a mouse model...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Tomas, Myreen E., Mana, Thriveen S. C., Wilson, Brigid M., Nerandzic, Michelle M., Joussef-Piña, Samira, Quiñones-Mateu, Miguel E., Donskey, Curtis J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923165/
https://ncbi.nlm.nih.gov/pubmed/29530853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02237-17
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