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Use of weighted multivariate estimates in trials of multi-serotype vaccines to simplify interpretation of treatment differences

BACKGROUND: Many vaccines contain multiple components. Licensed pneumococcal conjugate vaccines (PCV) contain polysaccharides from 7, 10, or 13 different serotypes of Streptococcus pneumoniae. The main outcomes in randomised trials of pneumococcal vaccines are serotype-specific antibody measures. Co...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Voysey, Merryn, Pollard, Andrew J., Perera, Rafael, Shrestha, Shrijana, Thorson, Stephen, Fanshawe, Thomas R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922548/
https://ncbi.nlm.nih.gov/pubmed/29702658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196200
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