Use of weighted multivariate estimates in trials of multi-serotype vaccines to simplify interpretation of treatment differences

BACKGROUND: Many vaccines contain multiple components. Licensed pneumococcal conjugate vaccines (PCV) contain polysaccharides from 7, 10, or 13 different serotypes of Streptococcus pneumoniae. The main outcomes in randomised trials of pneumococcal vaccines are serotype-specific antibody measures. Co...

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Bibliographic Details
Published in:PLoS One
Main Authors: Voysey, Merryn, Pollard, Andrew J., Perera, Rafael, Shrestha, Shrijana, Thorson, Stephen, Fanshawe, Thomas R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922548/
https://ncbi.nlm.nih.gov/pubmed/29702658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196200
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