LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity

Excess lipid accumulation is an early signature of nonalcoholic fatty liver disease (NAFLD). Although liver receptor homolog 1 (LRH-1) (encoded by NR5A2) is suppressed in human NAFLD, evidence linking this phospholipid-bound nuclear receptor to hepatic lipid metabolism is lacking. Here, we report an...

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Pubblicato in:JCI Insight
Autori principali: Miranda, Diego A., Krause, William C., Cazenave-Gassiot, Amaury, Suzawa, Miyuki, Escusa, Hazel, Foo, Juat Chin, Shihadih, Diyala S., Stahl, Andreas, Fitch, Mark, Nyangau, Edna, Hellerstein, Marc, Wenk, Markus R., Silver, David L., Ingraham, Holly A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922282/
https://ncbi.nlm.nih.gov/pubmed/29515023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96151
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