An APRIL-based chimeric antigen receptor for dual targeting of BCMA and TACI in multiple myeloma

B-cell maturation antigen (BCMA) is a promising therapeutic target for multiple myeloma (MM), but expression is variable, and early reports of BCMA targeting chimeric antigen receptors (CARs) suggest antigen downregulation at relapse. Dual-antigen targeting increases targetable tumor antigens and re...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Lee, Lydia, Draper, Benjamin, Chaplin, Neil, Philip, Brian, Chin, Melody, Galas-Filipowicz, Daria, Onuoha, Shimobi, Thomas, Simon, Baldan, Vania, Bughda, Reyisa, Maciocia, Paul, Kokalaki, Eva, Neves, Margarida P., Patel, Dominic, Rodriguez-Justo, Manuel, Francis, James, Yong, Kwee, Pule, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922275/
https://ncbi.nlm.nih.gov/pubmed/29284597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-781351
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