SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut microbiota in type 2 diabetic mice

BACKGROUND: Type 2 diabetes (T2D) is associated with generalized vascular dysfunction characterized by increases in large artery stiffness, endothelial dysfunction, and vascular smooth muscle dysfunction. Sodium glucose cotransporter 2 inhibitors (SGLT2i) represent the most recently approved class o...

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Publicat a:Cardiovasc Diabetol
Autors principals: Lee, Dustin M., Battson, Micah L., Jarrell, Dillon K., Hou, Shuofei, Ecton, Kayl E., Weir, Tiffany L., Gentile, Christopher L.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Original Investigation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921754/
https://ncbi.nlm.nih.gov/pubmed/29703207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-018-0708-x
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