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Cell‐killing Efficiency and Number of Platinum Atoms Binding to DNA, RNA and Protein Molecules of HeLa Cells Treated with Combinations of trans‐Diammedichloroplatinum(II) and Hyperthermia

The effect of hyperthermia on the cell‐killing efficiency of Pt atoms binding to DNA, RNA and protein molecules was examined. HeLa S‐3 cells were treated with (195m)Pt‐radiolabeled trans‐diaminedichloro‐platinum(II) (TDDP) for 60 min at various temperatures, and the relationship between the lethal e...

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Publicat a:Jpn J Cancer Res
Autors principals: Akaboshi, Mitsuhiko, Kawai, Kenichi, Kinashi, Yuko, Masunaga, Shinichiro, Ono, Koji
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 1997
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921455/
https://ncbi.nlm.nih.gov/pubmed/9247608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00410.x
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