Direct Intratumoral Gene Transfer of the Herpes Simplex Virus Thymidine Kinase Gene with DNA‐liposome Complexes: Growth Inhibition of Tumors and Lack of Localization in Normal Tissues

To constitute the site‐specific expression of the herpes simplex virus thymidine‐kinase (HSV‐TK) gene in tumor cells, we have assessed the promoter function of the simian virus 40 (SV40) promoter and the 5’flanking region of c‐erbB‐2 gene using a luciferase‐expressing reporter plasmid. After the tra...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Takakuwa, Koicni, Fujita, Kazuyuki, Kikuchi, Akira, Sugaya, Susumu, Yahata, Tetsuro, Aida, Hiroshi, Kurabayashi, Takumi, Hasegawa, Isao, Tanaka, Kenichi
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1997
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921354/
https://ncbi.nlm.nih.gov/pubmed/9119745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00362.x
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