Prevention by 2‐Mercaptoethane Sulfonate and N‐Acetylcysteine of Renal Oxidative Damage in Rats Treated with Ferric Nitrilotriacetate

Ferric nitrilotriacetate (Fe‐NTA) is a renal toxicant and carcinogen in rats and mice. We found that its administration results in formation of 4‐hydroxy‐2‐nonenal (HNE) in the renal proximal tubule cells of rats, and 8‐hydroxydeoxyguanosine (8‐OHdG) adducts in their DNA, suggesting a role for oxida...

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Vydáno v:Jpn J Cancer Res
Hlavní autoři: Umemura, Takashi, Hasegawa, Ryuichi, Sai‐Kato, Kimie, Nishikawa, Akiyoshi, Furukawa, Fumio, Toyokuni, Shinya, Uchida, Koji, Inoue, Tohru, Kurokawa, Yuji
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 1996
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921195/
https://ncbi.nlm.nih.gov/pubmed/8878448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1996.tb02115.x
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