Direct Transplantation of Chronic Myelogenous Leukemia Cells into Nude Mice and Establishment of a Leukemic Stem Cell (Ph(1+), CD34(+)) Line Dependent on Mouse Bone Marrow Stromal Cells in vitro

Peripheral blood cells from a female patient with Ph(1)‐positive chronic myelogenous leukemia (CML) in blast crisis were serially transplanted in BALB/c nude mice for 16 passages. This in vivo cell line, designated CML‐N‐1, had Ph(1)chromosome abnormality and BCR gene rearrangement. The cells expres...

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Pubblicato in:Jpn J Cancer Res
Autori principali: Kubonishi, Ichiro, Takeuchi, Seisho, Uemura, Yoshiki, Kamioka, Mikio, Asahi, Yasutomo, Ohtsuki, Yuji, Miyoshi, Isao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 1995
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920846/
https://ncbi.nlm.nih.gov/pubmed/7540608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1995.tb03078.x
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