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Long‐term Exposure to the Anti‐inflammatory Agent Phenylbutazone Induces Kidney Tumors in Rats and Liver Tumors in Mice
Long‐term toxicity and carcinogenicity of phenylbutazone, a nonsteroidal anti‐inflammatory drug, were evaluated in F344/N rats and B6C3F1 mice. In 2‐year studies, phenylbutazone was given in corn oil by gavage 5 days per week to groups of 50 rats of each sex at doses of 0, 50, or 100 mg/kg body weig...
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| Udgivet i: | Jpn J Cancer Res |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Blackwell Publishing Ltd
1995
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5920813/ https://ncbi.nlm.nih.gov/pubmed/7744695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1995.tb03048.x |
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