Low Incidence of Point Mutations in H‐, K‐ and N‐ras Oncogenes and p53 Tumor Suppressor Gene in Renal Cell Carcinoma and Peritoneal Mesothelioma of Wistar Rats Induced by Ferric Nitrilotriacetate

An iron chelate, ferric nitrilotriacetate (Fe‐NTA), induces renal proximal tubular damage, a consequence of iron‐catalyzed free radical reactions, that finally leads to a high incidence of renal cell carcinoma (RCC) in rodents. Previous studies have identified, within 24 h after administration of Fe...

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Publicat a:Jpn J Cancer Res
Autors principals: Nishiyama, Yasuyuki, Suwa, Hirofumi, Okamoto, Keisei, Fukumoto, Manabu, Hiai, Hiroshi, Toyokuni, Shinya
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 1995
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920660/
https://ncbi.nlm.nih.gov/pubmed/8636003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1995.tb03308.x
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