Stochastic Pharmacokinetic-Pharmacodynamic Modeling for Assessing the Systemic Health Risk of Perfluorooctanoate (PFOA)

A phase 1 dose-escalation trial assessed the chemotherapeutic potential of ammonium perfluorooctanoate (APFO). Forty-nine primarily solid-tumor cancer patients who failed standard therapy received weekly APFO doses (50–1200 mg) for 6 weeks. Clinical chemistries and plasma PFOA (anionic APFO) were me...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Convertino, Matteo, Church, Timothy R, Olsen, Geary W, Liu, Yang, Doyle, Eddie, Elcombe, Clifford R, Barnett, Anna L, Samuel, Leslie M, MacPherson, Iain R, Evans, Thomas R J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Pbpk Modeling for Pfoa Risk
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920327/
https://ncbi.nlm.nih.gov/pubmed/29462473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy035
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