Expression and Function of IL12/23 Related Cytokine Subunits (p35, p40, and p19) in Giant-Cell Arteritis Lesions: Contribution of p40 to Th1- and Th17-Mediated Inflammatory Pathways

BACKGROUND: Giant-cell arteritis (GCA) is considered a T helper (Th)1- and Th17-mediated disease. Interleukin (IL)-12 is a heterodimeric cytokine (p35/p40) involved in Th1 differentiation. When combining with p19 subunit, p40 compose IL-23, a powerful pro-inflammatory cytokine that maintains Th17 re...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Espígol-Frigolé, Georgina, Planas-Rigol, Ester, Lozano, Ester, Corbera-Bellalta, Marc, Terrades-García, Nekane, Prieto-González, Sergio, García-Martínez, Ana, Hernández-Rodríguez, Jose, Grau, Josep M., Cid, Maria C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920281/
https://ncbi.nlm.nih.gov/pubmed/29731755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00809
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