Internalization of CD239 highly expressed in breast cancer cells: a potential antigen for antibody-drug conjugates

Antibody–drug conjugates (ADCs) are attractive in cancer therapy because they can directly bind to cancer cells and provide anticancer activity. To kill cancer cells with ADCs, the target antigens are required not only to be highly and/or selectively expressed on cancer cells but also internalized b...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Kikkawa, Yamato, Enomoto-Okawa, Yurie, Fujiyama, Aiko, Fukuhara, Takeshi, Harashima, Nozomi, Sugawara, Yumika, Negishi, Yoichi, Katagiri, Fumihiko, Hozumi, Kentaro, Nomizu, Motoyoshi, Ito, Yuji
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919910/
https://ncbi.nlm.nih.gov/pubmed/29700410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24961-4
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