Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions

The growth plate mediates bone growth where SOX9 and GLI factors control chondrocyte proliferation, differentiation and entry into hypertrophy. FOXA factors regulate hypertrophic chondrocyte maturation. How these factors integrate into a Gene Regulatory Network (GRN) controlling these differentiatio...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Tan, Zhijia, Niu, Ben, Tsang, Kwok Yeung, Melhado, Ian G., Ohba, Shinsuke, He, Xinjun, Huang, Yongheng, Wang, Cheng, McMahon, Andrew P., Jauch, Ralf, Chan, Danny, Zhang, Michael Q., Cheah, Kathryn S. E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919691/
https://ncbi.nlm.nih.gov/pubmed/29659575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007346
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