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Enhanced Antitumor Activity and Reduced Toxicity of 1,3‐Bis(2‐chloroethyl)‐1‐nitrosourea Administered in Lipid Microspheres to Tumor‐bearing Mice

Stable lipid microspheres (LM) and lipid nanospheres (LN) with average diameters of 200 nm and 50 nm, respectively, were used to encapsulate an lipophilic antitumor agent, 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea (BCNU). LM and LN containing BCNU (lipo BCNU and s‐lipo BCNU, respectively) were prepared b...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Takenaga, Mitsuko, Igarashi, Rie, Tsuji, Hiroaki, Mizushima, Yutaka
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1993
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919066/
https://ncbi.nlm.nih.gov/pubmed/8226282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1993.tb02804.x
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