Evidence of Direct Generation of Oxygen Free Radicals from Heterocyclic Amines by NADPH/Cytochrome P‐450 Reductase in vitro

Highly purified cytochrome P‐450 reductase (also called cytochrome c reductase; EC 1.6.2.4.) and NADPH were used to generate superoxide radical (O(2)) from 11 different heterocyclic amines (HCAs) as identified by electron spin resonance spectroscopy using the spin trapping method with 5,5‐dimethyl‐1...

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Bibliographic Details
Published in:Jpn J Cancer Res
Main Authors: Sato, Keizo, Akaike, Takaaki, Kojima, Yuichiro, Ando, Masayuki, Nagao, Minako, Maeda, Hiroshi
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 1992
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918710/
https://ncbi.nlm.nih.gov/pubmed/1336493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1992.tb02746.x
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