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Long‐lasting Accumulation of Vinblastine in Inostamycin‐treated Multidrug‐resistant KB Cells

Inostamycin, a novel polyether compound, reverses multidrug resistance in KB cells. The mechanism of its action was studied by use of radioactively labeled vinblastine. Inostamycin dose‐dependently increased the accumulation of [(3)H] vinblastine in multidrug‐resistant KB‐C4 cells at 0.5‐2 μg/ml, wh...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Kawada, Manabu, Umezawa, Kazuo
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1991
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918255/
https://ncbi.nlm.nih.gov/pubmed/1955381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1991.tb01771.x
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