Urothelial Damage and Tumor Initiation by Urinary Metabolites of Sodium o‐Phenylphenate in the Urinary Bladder of Female Rats

Intravesical instillation of 2‐phenyl‐1,4‐benzoquinone (PBQ), a metabolite of sodium o‐phenylphenate (Na‐OPP), at a concentration of 0.1% in saline caused acute epithelial injury, prolonged inflammation and epithelial hyperplasia in female F344 rats. Ten such instillations of PBQ within 5 weeks resu...

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Publicado en:Jpn J Cancer Res
Autores principales: Hasegawa, Ryohei, Furukawa, Fumio, Toyoda, Kazuhiro, Sato, Hidetaka, Takahashi, Michihito, Hayashi, Yuzo
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 1990
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918068/
https://ncbi.nlm.nih.gov/pubmed/2116397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1990.tb02595.x
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