Kinetics of Internalization and Cytotoxicity of Transferrin‐Neocarzinostatin Conjugate in Human Leukemia Cell Line, K562

Human serum transferrin was conjugated with an anticancer‐active polypeptide, neocarzinostatin, by using N‐succinimidy1‐3‐(2‐pyridyldithio)propionate. The conjugate consisted of 1.8 mol of neocarzinostatin per 1 mol of transferrin on average and retained cytotoxic activity against human tumor cells....

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Veröffentlicht in:Jpn J Cancer Res
Hauptverfasser: Kohgo, Yutaka, Kondo, Hitoshi, Kato, Junji, Sasaki, Katsunori, Tsushima, Nobuyasu, Nishisato, Takuji, Hirayama, Michiaki, Fujikawa, Koshi, Shintani, Naoaki, Mogi, Yoshihiro, Niitsu, Yoshiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 1990
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5917957/
https://ncbi.nlm.nih.gov/pubmed/2139019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1990.tb02512.x
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