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Overactive autophagy is a pathological mechanism underlying premature suture ossification in nonsyndromic craniosynostosis

Nonsyndromic craniosynostosis (NSC) is the most common craniosynostosis with the primary defect being one or more fused sutures. In contrast to syndromic craniosynostosis, the etiopathogenesis of NSC is largely unknown. Here we show that autophagy, a major catabolic process required for the maintena...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Qiu, Shanshan, Wang, Jing, Huang, Siqi, Sun, Shouqing, Zhang, Zhen, Bao, Nan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916928/
https://ncbi.nlm.nih.gov/pubmed/29695736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24885-z
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