Innate immune activation by cGAMP-PC7A nanoparticles leads to potent and long-acting antiretroviral response against HIV-1

HIV-1 evades immune detection by the cGAS-STING cytosolic DNA sensing pathway during acute infection. STING is a critical mediator of type I interferon production, and STING agonists such as cyclic GMP-AMP (cGAMP) and other cyclic dinucleotides elicit potent immune and anti-tumor response. Here, we...

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Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Aroh, Chukwuemika, Wang, Zhaohui, Dobbs, Nicole, Luo, Min, Chen, Zhijian, Gao, Jinming, Yan, Nan
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916791/
https://ncbi.nlm.nih.gov/pubmed/29084836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700972
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