Neuropsychiatric Phenotypes Produced by GABA Reduction in Mouse Cortex and Hippocampus

Whereas cortical GAD67 reduction and subsequent GABA level decrease are consistently observed in schizophrenia and depression, it remains unclear how these GABAergic abnormalities contribute to specific symptoms. We modeled cortical GAD67 reduction in mice, in which the Gad1 gene is genetically abla...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Kolata, Stefan M, Nakao, Kazuhito, Jeevakumar, Vivek, Farmer-Alroth, Emily L, Fujita, Yuko, Bartley, Aundrea F, Jiang, Sunny Zhihong, Rompala, Gregory R, Sorge, Robert E, Jimenez, Dennisse V, Martinowich, Keri, Mateo, Yolanda, Hashimoto, Kenji, Dobrunz, Lynn E, Nakazawa, Kazu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916365/
https://ncbi.nlm.nih.gov/pubmed/29362511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2017.296
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