Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors

Humans with 15q13.3 microdeletion syndrome (15q13.3DS) are typically hemizygous for CHRNA7, the gene coding for the α7 nicotinic acetylcholine receptor (nAChR), and manifest a variable neuropsychiatric phenotype that frequently includes persistent aggression. In mice, nAChR activation by nicotine is...

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Publicat a:Neuropsychopharmacology
Autors principals: Lewis, Alan S, Pittenger, Steven T, Mineur, Yann S, Stout, Dawson, Smith, Philip H, Picciotto, Marina R
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2018
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916354/
https://ncbi.nlm.nih.gov/pubmed/29114104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2017.276
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