Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in Escherichia coli

Although the TEM-1 β-lactamase (Bla(TEM-1)) hydrolyzes penicillins and narrow-spectrum cephalosporins, organisms expressing this enzyme are typically susceptible to β-lactam/β-lactamase inhibitor combinations such as piperacillin-tazobactam (TZP). However, our previous work led to the discovery of 2...

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Publicado en:mBio
Main Authors: Schechter, Lisa M., Creely, David P., Garner, Cherilyn D., Shortridge, Dee, Nguyen, Hoan, Chen, Lei, Hanson, Blake M., Sodergren, Erica, Weinstock, George M., Dunne, W. Michael, van Belkum, Alex, Leopold, Shana R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2018
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915731/
https://ncbi.nlm.nih.gov/pubmed/29691340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00583-18
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