Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in Escherichia coli

Although the TEM-1 β-lactamase (Bla(TEM-1)) hydrolyzes penicillins and narrow-spectrum cephalosporins, organisms expressing this enzyme are typically susceptible to β-lactam/β-lactamase inhibitor combinations such as piperacillin-tazobactam (TZP). However, our previous work led to the discovery of 2...

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Vydáno v:mBio
Hlavní autoři: Schechter, Lisa M., Creely, David P., Garner, Cherilyn D., Shortridge, Dee, Nguyen, Hoan, Chen, Lei, Hanson, Blake M., Sodergren, Erica, Weinstock, George M., Dunne, W. Michael, van Belkum, Alex, Leopold, Shana R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915731/
https://ncbi.nlm.nih.gov/pubmed/29691340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00583-18
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