Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons

Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch after nerve injury in mice. Mice in which Trk...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Dhandapani, Rahul, Arokiaraj, Cynthia Mary, Taberner, Francisco J., Pacifico, Paola, Raja, Sruthi, Nocchi, Linda, Portulano, Carla, Franciosa, Federica, Maffei, Mariano, Hussain, Ahmad Fawzi, de Castro Reis, Fernanda, Reymond, Luc, Perlas, Emerald, Garcovich, Simone, Barth, Stefan, Johnsson, Kai, Lechner, Stefan G., Heppenstall, Paul A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915601/
https://ncbi.nlm.nih.gov/pubmed/29691410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04049-3
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