Circulating tumor DNA in early response assessment and monitoring of advanced colorectal cancer treated with a multi-kinase inhibitor

Predictive biomarkers are eagerly awaited in advanced colorectal cancer (aCRC). Targeted sequencing performed on tumor and baseline plasma samples in 20 patients with aCRC treated with regorafenib identified 89 tumor-specific mutations of which ≥50% are also present in baseline plasma. Droplet digit...

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Udgivet i:Oncotarget
Main Authors: Vandeputte, Caroline, Kehagias, Pashalina, El Housni, Hakim, Ameye, Lieveke, Laes, Jean-François, Desmedt, Christine, Sotiriou, Christos, Deleporte, Amélie, Puleo, Francesco, Geboes, Karen, Delaunoit, Thierry, Demolin, Gauthier, Peeters, Marc, D’Hondt, Lionel, Janssens, Jos, Carrasco, Javier, Marechal, Raphaël, Galdon, Maria Gomez, Heimann, Pierre, Paesmans, Marianne, Flamen, Patrick, Hendlisz, Alain
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915153/
https://ncbi.nlm.nih.gov/pubmed/29707145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24879
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