TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators

TGFB1 (transforming growth factor beta 1) is a potent cytokine playing a driving role in development, fibrosis and cancer. It is synthesized as prodomain-growth factor complex that requires tethering to LTBP (latent transforming growth factor beta binding protein) for efficient secretion into the ex...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Nüchel, Julian, Ghatak, Sushmita, Zuk, Alexandra V., Illerhaus, Anja, Mörgelin, Matthias, Schönborn, Katrin, Blumbach, Katrin, Wickström, Sara A., Krieg, Thomas, Sengle, Gerhard, Plomann, Markus, Eckes, Beate
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Papers - Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915026/
https://ncbi.nlm.nih.gov/pubmed/29297744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1422850
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