Anti-HMGB1 Neutralizing Antibody Attenuates Periodontal Inflammation and Bone Resorption in a Murine Periodontitis Model

High mobility group box 1 (HMGB1) is a non-histone DNA-binding protein that is secreted into the extracellular milieu in response to inflammatory stimuli. The secreted HMGB1 mediates various inflammatory diseases, including periodontitis; however, the underlying mechanisms of HMGB1-induced periodont...

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Detalles Bibliográficos
Publicado en:Infect Immun
Main Authors: Yoshihara-Hirata, Chiaki, Yamashiro, Keisuke, Yamamoto, Tadashi, Aoyagi, Hiroaki, Ideguchi, Hidetaka, Kawamura, Mari, Suzuki, Risa, Ono, Mitsuaki, Wake, Hidenori, Nishibori, Masahiro, Takashiba, Shogo
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2018
Assuntos:
Host Response and Inflammation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913859/
https://ncbi.nlm.nih.gov/pubmed/29531138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00111-18
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