Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium

BACKGROUND: Polygenic risk scores (PRS) for breast cancer can be used to stratify the population into groups at substantially different levels of risk. Combining PRS and environmental risk factors will improve risk prediction; however, integrating PRS into risk prediction models requires evaluation...

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Detalhes bibliográficos
Publicado no:Int J Epidemiol
Main Authors: Rudolph, Anja, Song, Minsun, Brook, Mark N, Milne, Roger L, Mavaddat, Nasim, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Wilcox, Amber N, Hopper, John L, Southey, Melissa C, Keeman, Renske, Fasching, Peter A, Beckmann, Matthias W, Gago-Dominguez, Manuela, Castelao, Jose E, Guénel, Pascal, Truong, Thérèse, Bojesen, Stig E, Flyger, Henrik, Brenner, Hermann, Arndt, Volker, Brauch, Hiltrud, Brüning, Thomas, Mannermaa, Arto, Kosma, Veli-Matti, Lambrechts, Diether, Keupers, Machteld, Couch, Fergus J, Vachon, Celine, Giles, Graham G, MacInnis, Robert J, Figueroa, Jonine, Brinton, Louise, Czene, Kamila, Brand, Judith S, Gabrielson, Marike, Humphreys, Keith, Cox, Angela, Cross, Simon S, Dunning, Alison M, Orr, Nick, Swerdlow, Anthony, Hall, Per, Pharoah, Paul D P, Schmidt, Marjanka K, Easton, Douglas F, Chatterjee, Nilanjan, Chang-Claude, Jenny, García-Closas, Montserrat
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Genetic Epidemiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913605/
https://ncbi.nlm.nih.gov/pubmed/29315403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ije/dyx242
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