Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium

BACKGROUND: Polygenic risk scores (PRS) for breast cancer can be used to stratify the population into groups at substantially different levels of risk. Combining PRS and environmental risk factors will improve risk prediction; however, integrating PRS into risk prediction models requires evaluation...

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Publicado en:Int J Epidemiol
Autores principales: Rudolph, Anja, Song, Minsun, Brook, Mark N, Milne, Roger L, Mavaddat, Nasim, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Wilcox, Amber N, Hopper, John L, Southey, Melissa C, Keeman, Renske, Fasching, Peter A, Beckmann, Matthias W, Gago-Dominguez, Manuela, Castelao, Jose E, Guénel, Pascal, Truong, Thérèse, Bojesen, Stig E, Flyger, Henrik, Brenner, Hermann, Arndt, Volker, Brauch, Hiltrud, Brüning, Thomas, Mannermaa, Arto, Kosma, Veli-Matti, Lambrechts, Diether, Keupers, Machteld, Couch, Fergus J, Vachon, Celine, Giles, Graham G, MacInnis, Robert J, Figueroa, Jonine, Brinton, Louise, Czene, Kamila, Brand, Judith S, Gabrielson, Marike, Humphreys, Keith, Cox, Angela, Cross, Simon S, Dunning, Alison M, Orr, Nick, Swerdlow, Anthony, Hall, Per, Pharoah, Paul D P, Schmidt, Marjanka K, Easton, Douglas F, Chatterjee, Nilanjan, Chang-Claude, Jenny, García-Closas, Montserrat
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
Materias:
Genetic Epidemiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913605/
https://ncbi.nlm.nih.gov/pubmed/29315403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ije/dyx242
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