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In vitro and in vivo effects of MK2206 and chloroquine combination therapy on endometriosis: autophagy may be required for regrowth of endometriosis

BACKGROUND AND PURPOSE: A high recurrence rate after medical treatment is a major clinical problem for patients with endometriosis. Here, we have evaluated the in vitro effects of combined treatment with MK2206 (an AKT inhibitor) + chloroquine on cell growth and regrowth of endometriotic stromal cel...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Matsuzaki, Sachiko, Pouly, Jean‐Luc, Canis, Michel
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913408/
https://ncbi.nlm.nih.gov/pubmed/29457968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14170
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