Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)

The misfolding and accumulation of tau protein into intracellular aggregates known as neurofibrillary tangles is a pathological hallmark of neurodegenerative diseases such as Alzheimer’s disease. However, while tau propagation is a known marker for disease progression, exactly how tau propagates fro...

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Udgivet i:Sci Rep
Main Authors: Rauch, Jennifer N., Chen, John J., Sorum, Alexander W., Miller, Gregory M., Sharf, Tal, See, Stephanie K., Hsieh-Wilson, Linda C., Kampmann, Martin, Kosik, Kenneth S.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913225/
https://ncbi.nlm.nih.gov/pubmed/29686391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24904-z
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