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Enhancing Efficacy and Stability of an Antiheroin Vaccine: Examination of Antinociception, Opioid Binding Profile, and Lethality

In recent years, drug conjugate vaccines have shown promise as therapeutics for substance use disorder. As a means to improve the efficacy of a heroin conjugate vaccine, we systematically explored 20 vaccine formulations with varying combinations of carrier proteins and adjuvants. In regard to adjuv...

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Publicat a:Mol Pharm
Autors principals: Hwang, Candy S., Bremer, Paul T., Wenthur, Cody J., Ho, Sam On, Chiang, SuMing, Ellis, Beverly, Zhou, Bin, Fujii, Gary, Janda, Kim D.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912936/
https://ncbi.nlm.nih.gov/pubmed/29420901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.7b00933
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