Intranasal administration of a two-dose adjuvanted multi-antigen TMV-subunit conjugate vaccine fully protects mice against Francisella tularensis LVS challenge

Tularemia is a fatal human disease caused by Francisella tularensis, a Gram-negative encapsulated coccobacillus bacterium. Due to its low infectious dose, ease of aerosolized transmission, and lethal effects, the CDC lists F. tularensis as a Category A pathogen, the highest level for a potential bio...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: McCormick, Alison A., Shakeel, Aisha, Yi, Chris, Kaur, Hardeep, Mansour, Ahd M., Bakshi, Chandra Shekhar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912714/
https://ncbi.nlm.nih.gov/pubmed/29684046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194614
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