Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

DNA damage induces specific signaling and repair responses in the cell, which is critical for protection of genome integrity. Laser microirradiation became a valuable experimental tool to investigate the DNA damage response (DDR) in vivo. It allows real-time high-resolution single-cell analysis of m...

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Bibliographic Details
Published in:J Vis Exp
Main Authors: Kong, Xiangduo, Cruz, Gladys M.S., Silva, Bárbara A., Wakida, Nicole M., Khatibzadeh, Nima, Berns, Michael W., Yokomori, Kyoko
Format: Artigo
Language:Inglês
Published: MyJove Corporation 2018
Subjects:
Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912314/
https://ncbi.nlm.nih.gov/pubmed/29443023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/56213
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