Nutritional Interventions for Mitochondrial OXPHOS Deficiencies: Mechanisms and Model Systems

Multi-system metabolic disorders caused by defects in oxidative phosphorylation (OXPHOS) are progressive and severely crippling, often lethal, conditions. Inborn errors of OXPHOS function are termed Primary Mitochondrial Disorders (PMDs), and the use of nutritional interventions is routine in PMD su...

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Veröffentlicht in:Annu Rev Pathol
Hauptverfasser: Kuszak, Adam J., Espey, Michael Graham, Falk, Marni J., Holmbeck, Marissa A., Manfredi, Giovanni, Shadel, Gerald S., Vernon, Hilary J., Zolkipli-Cunningham, Zarazuela
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5911915/
https://ncbi.nlm.nih.gov/pubmed/29099651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-pathol-020117-043644
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