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Insight from the maximal activation of the signal transduction excitable network in Dictyostelium discoideum
Cell migration requires the coordination of an excitable signal transduction network involving Ras and PI3K pathways with cytoskeletal activity. We show that expressing activated Ras GTPase-family proteins in cells lacking PTEN or other mutations which increase cellular protrusiveness transforms cel...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5910810/ https://ncbi.nlm.nih.gov/pubmed/29602807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710480115 |
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