A novel statistical method for assessing effective adherence to medication and calculating optimal drug dosages

OBJECTIVE: We derive a novel model-based metric for effective adherence to medication, and validate it using data from the INhaler Compliance Assessment device (INCA(TM)). This technique employs dose timing data to estimate the threshold drug concentration needed to maintain optimal health. METHODS:...

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Опубликовано в: :PLoS One
Главные авторы: Greene, Garrett, Costello, Richard W., Cushen, Breda, Sulaiman, Imran, Mac Hale, Elaine, Conroy, Ronan M., Doyle, Frank
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2018
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909911/
https://ncbi.nlm.nih.gov/pubmed/29677197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195663
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