Methotrexate limits inflammation through an A20-dependent cross-tolerance mechanism

OBJECTIVES: Methotrexate (MTX) is the anchor drug for treatment of rheumatoid arthritis (RA), but the mechanism of its anti-inflammatory action is not fully understood. In RA, macrophages display a proinflammatory polarisation profile that resembles granulocyte-macrophage colony-stimulating factor (...

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Udgivet i:Ann Rheum Dis
Main Authors: Municio, Cristina, Dominguez-Soto, Ángeles, Fuentelsaz-Romero, Sara, Lamana, Amalia, Montes, Nuria, Cuevas, Víctor D, Campos, Raquel García, Pablos, José L, González-Álvaro, Isidoro, Puig-Kröger, Amaya
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2018
Fag:
Basic and Translational Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909749/
https://ncbi.nlm.nih.gov/pubmed/29431121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2017-212537
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