Kill two birds with one stone: making multi-transgenic pre-diabetes mouse models through insulin resistance and pancreatic apoptosis pathogenesis

BACKGROUND: Type 2 diabetes is characterized by insulin resistance accompanied by defective insulin secretion. Transgenic mouse models play an important role in medical research. However, single transgenic mouse models may not mimic the complex phenotypes of most cases of type 2 diabetes. METHODS: F...

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Veröffentlicht in:PeerJ
Hauptverfasser: Kong, Siyuan, Ruan, Jinxue, Zhang, Kaiyi, Hu, Bingjun, Cheng, Yuzhu, Zhang, Yubo, Yang, Shulin, Li, Kui
Format: Artigo
Sprache:Inglês
Veröffentlicht: PeerJ Inc. 2018
Schlagworte:
Agricultural Science
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909684/
https://ncbi.nlm.nih.gov/pubmed/29682407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.4542
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