Trivalent CAR T cells overcome interpatient antigenic variability in glioblastoma

BACKGROUND: Glioblastoma (GBM) is the most common primary malignant brain cancer, and is currently incurable. Chimeric antigen receptor (CAR) T cells have shown promise in GBM treatment. While we have shown that combinatorial targeting of 2 glioma antigens offsets antigen escape and enhances T-cell...

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Podrobná bibliografie
Vydáno v:Neuro Oncol
Hlavní autoři: Bielamowicz, Kevin, Fousek, Kristen, Byrd, Tiara T, Samaha, Hebatalla, Mukherjee, Malini, Aware, Nikita, Wu, Meng-Fen, Orange, Jordan S, Sumazin, Pavel, Man, Tsz-Kwong, Joseph, Sujith K, Hegde, Meenakshi, Ahmed, Nabil
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909636/
https://ncbi.nlm.nih.gov/pubmed/29016929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox182
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