The Absence of Indoleamine 2,3-Dioxygenase Inhibits Retinal Capillary Degeneration in Diabetic Mice

PURPOSE: Loss of retinal capillary endothelial cells and pericytes through apoptosis is an early event in diabetic retinopathy (DR). Inflammatory pathways play a role in early DR, yet the biochemical mechanisms are poorly understood. In this study, we investigated the role of indoleamine 2,3-dioxyge...

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Dettagli Bibliografici
Pubblicato in:Invest Ophthalmol Vis Sci
Autori principali: Nahomi, Rooban B., Sampathkumar, Sruthi, Myers, Angela M., Elghazi, Lynda, Smith, Dawn G., Tang, Jie, Lee, C. Allen, Kern, Timothy S., Nagaraj, Ram H., Fort, Patrice E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Association for Research in Vision and Ophthalmology 2018
Soggetti:
Retina
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908388/
https://ncbi.nlm.nih.gov/pubmed/29677366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-22702
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