Copy number changes at 8p11-12 predict adverse clinical outcome and chemo- and radiotherapy response in breast cancer

PURPOSE: The short arm of chromosome 8 (8p) is a frequent target of loss of heterozygosity (LOH) in cancer, and 8p LOH is commonly associated with a more aggressive tumor phenotype. The 8p11-12 region is a recurrent breakpoint area characterized by a sharp decrease in gains/amplifications and increa...

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Udgivet i:Oncotarget
Main Authors: Moelans, Cathy B., van Maldegem, Caroline M. G., van der Wall, Elsken, van Diest, Paul J.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908307/
https://ncbi.nlm.nih.gov/pubmed/29682206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24904
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