CTCF-KDM4A complex correlates with histone modifications that negatively regulate CHD5 gene expression in cancer cell lines

Histone demethylase KDM4A is involved in H3K9me3 and H3K36me3 demethylation, which are epigenetic modifications associated with gene silencing and RNA Polymerase II elongation, respectively. KDM4A is abnormally expressed in cancer, affecting the expression of multiple targets, such as the CHD5 gene....

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Publicat a:Oncotarget
Autors principals: Guerra-Calderas, Lissania, González-Barrios, Rodrigo, Patiño, Carlos César, Alcaraz, Nicolás, Salgado-Albarrán, Marisol, de León, David Cantú, Hernández, Clementina Castro, Sánchez-Pérez, Yesennia, Maldonado-Martínez, Héctor Aquiles, De la Rosa-Velazquez, Inti A., Vargas-Romero, Fernanda, Herrera, Luis A., García-Carrancá, Alejandro, Soto-Reyes, Ernesto
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2018
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908303/
https://ncbi.nlm.nih.gov/pubmed/29682202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24798
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