CTCF-KDM4A complex correlates with histone modifications that negatively regulate CHD5 gene expression in cancer cell lines

Histone demethylase KDM4A is involved in H3K9me3 and H3K36me3 demethylation, which are epigenetic modifications associated with gene silencing and RNA Polymerase II elongation, respectively. KDM4A is abnormally expressed in cancer, affecting the expression of multiple targets, such as the CHD5 gene....

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Guerra-Calderas, Lissania, González-Barrios, Rodrigo, Patiño, Carlos César, Alcaraz, Nicolás, Salgado-Albarrán, Marisol, de León, David Cantú, Hernández, Clementina Castro, Sánchez-Pérez, Yesennia, Maldonado-Martínez, Héctor Aquiles, De la Rosa-Velazquez, Inti A., Vargas-Romero, Fernanda, Herrera, Luis A., García-Carrancá, Alejandro, Soto-Reyes, Ernesto
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908303/
https://ncbi.nlm.nih.gov/pubmed/29682202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24798
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