Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice

BACKGROUND & AIMS: Ceramide, a sphingolipid metabolite, affects T-cell signaling, induces apoptosis of cancer cells, and slows tumor growth in mice. However, it has not been used as a chemotherapeutic agent because of its cell impermeability and precipitation in aqueous solution. We developed a...

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Détails bibliographiques
Publié dans:Gastroenterology
Auteurs principaux: Li, Guangfu, Liu, Dai, Kimchi, Eric T., Kaifi, Jussuf T., Qi, Xiaoqiang, Manjunath, Yariswamy, Liu, Xinjian, Deering, Tye, Avella, Diego M., Fox, Todd, Rockey, Don C., Schell, Todd D., Kester, Mark, Staveley-O’Carroll, Kevin F.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908238/
https://ncbi.nlm.nih.gov/pubmed/29408569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.10.050
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