An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans

Purpura fulminans is a deadly complication of Neisseria meningitidis infections due to extensive thrombosis of microvessels. Although a Disseminated Intra-vascular Coagulation syndrome (DIC) is frequently observed during Gram negative sepsis, it is rarely associated with extensive thrombosis like th...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Lécuyer, Hervé, Virion, Zoé, Barnier, Jean-Philippe, Matczak, Soraya, Bourdoulous, Sandrine, Bianchini, Elsa, Saller, François, Borgel, Delphine, Nassif, Xavier, Coureuil, Mathieu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908201/
https://ncbi.nlm.nih.gov/pubmed/29630665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006981
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