A High-Throughput Time-Resolved Fluorescence Energy Transfer Assay to Screen for Modulators of RGS7/Gβ5/R7BP Complex

G protein-coupled receptors (GPCRs) are excellent drug targets exploited by majority of the Food and Drug Administration-approved medications, but when modulated, are often accompanied by significant adverse effects. Targeting of other elements in GPCR pathways for improved safety and efficacy is th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Assay Drug Dev Technol
Prif Awduron: Muntean, Brian S., Patil, Dipak N., Madoux, Franck, Fossetta, James, Scampavia, Louis, Spicer, Timothy P., Martemyanov, Kirill A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Mary Ann Liebert, Inc. 2018
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906730/
https://ncbi.nlm.nih.gov/pubmed/29658790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2017.839
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