A High-Throughput Time-Resolved Fluorescence Energy Transfer Assay to Screen for Modulators of RGS7/Gβ5/R7BP Complex

G protein-coupled receptors (GPCRs) are excellent drug targets exploited by majority of the Food and Drug Administration-approved medications, but when modulated, are often accompanied by significant adverse effects. Targeting of other elements in GPCR pathways for improved safety and efficacy is th...

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Publicado en:Assay Drug Dev Technol
Main Authors: Muntean, Brian S., Patil, Dipak N., Madoux, Franck, Fossetta, James, Scampavia, Louis, Spicer, Timothy P., Martemyanov, Kirill A.
Formato: Artigo
Idioma:Inglês
Publicado: Mary Ann Liebert, Inc. 2018
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906730/
https://ncbi.nlm.nih.gov/pubmed/29658790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2017.839
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